Wednesday, October 5, 2022

Toray looking scale up bio-based adipic acid capabilities

 Toray looking scale up bio-based adipic acid capabilities

Japan-based Toray Industries announced that it has developed the “world’s first” 100% bio-based adipic acid, a raw material for nylon 66 (polyamide 66), from sugars derived from inedible biomass. This achievement came from using a proprietary synthesis technique combining the company’s microbial fermentation technology and chemical purification technology that harnesses separation membranes. The company has started to scale up its capabilities in this area. It will test polymerisation of nylon 66, develop production technology, conduct market research, and take steps to commercialise applications for this biobased adipic acid by around 2030. Nylon 66 has been used for many years in fibres, resins, and other applications due to its exceptionally durable, strong, and rigid properties. Pressures to develop eco-friendly nylon 66 have risen in recent years amid a growing awareness of the need to realise a sustainable society. One challenge is that conventional chemical synthesis for producing adipic acid, the raw material of nylon 66, generates a greenhouse gas called nitrous oxide. Toray was the first in the world to discover microorganisms that produce an adipic acid intermediate from sugars. 


The company reconfigured metabolic pathways within microorganisms to enhance production efficiency by applying genetic engineering technology, which artificially recombines genes to streamline synthesis in microorganisms. It also employed bioinformatics technologies to design optimal microbial fermentation pathways for synthesis. Quantity of the intermediate synthesised by microorganisms has increased more than 1,000-fold since the initial discovery, and the efficiency of synthesis has improved dramatically. Toray is using reverse osmosis separation membranes to concentrate the intermediate in the purification process. This approach is more energy efficient than other methods that do not use these membranes. This bio-adipic acid production technique is free of nitrous oxide emissions, unlike the manufacturing processes for petroleum-derived adipic acid, and is expected to help combat global warming

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